1. Name and Synonyms

The product is officially named Tildipirosin and is commonly referred to by this name in veterinary applications. This standardized name ensures clear identification in clinical and research contexts.

2. Chemical Identification

Tildipirosin is identified by the CAS number 328898-40-4, serving as a unique identifier in the veterinary and pharmaceutical fields. This CAS number supports precise tracking in research, production, and quality control processes.

3. Appearance and Physical Properties

Tildipirosin typically appears as a pale yellow to yellow powder. This characteristic aids in product identification and quality control during manufacturing and distribution.

4. Purity and Solubility

Tildipirosin has a high purity level of ≥ 98%, ensuring reliable efficacy in veterinary applications. It is slightly soluble in water and soluble in organic solvents like methanol, making it adaptable for various formulations, including injectable solutions.

5. Molecular Structure

The molecular formula of Tildipirosin is C₄₁H₆₈N₂O₁₄, with a molecular weight of approximately 817.0 g/mol. Its structure enables it to inhibit bacterial protein synthesis, making it a powerful option for managing respiratory infections in livestock.

1. Antibiotic Type

Tildipirosin is a macrolide antibiotic, specifically designed to target respiratory pathogens in livestock. It inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, effectively blocking bacterial growth and replication. This mechanism makes Tildipirosin highly effective for treating respiratory infections in cattle and swine, particularly in cases where single-dose treatment is advantageous.

2. Antibacterial Spectrum

2.1 Gram-Negative Bacteria

Tildipirosin is particularly effective against several Gram-negative respiratory pathogens, including Mannheimia haemolytica, Pasteurella multocida, and Histophilus somni. These bacteria are commonly associated with Bovine Respiratory Disease (BRD) and other respiratory infections in cattle, which can significantly impact animal health and productivity. Tildipirosin’s efficacy against these pathogens makes it a valuable option for respiratory disease management in cattle.

2.2 Gram-Positive Bacteria

While primarily targeting Gram-negative bacteria, Tildipirosin also demonstrates activity against some Gram-positive organisms, such as Arcanobacterium pyogenes, which are sometimes involved in respiratory and systemic infections. This additional activity broadens its usefulness in treating mixed infections.

2.3 Mycoplasmas

Tildipirosin is highly effective against Mycoplasma bovis, a significant respiratory pathogen in cattle. Mycoplasma bovis is known to cause chronic respiratory infections, which are particularly problematic in intensive livestock farming. Tildipirosin’s action against Mycoplasma bovis is a key advantage, as this organism is resistant to many other types of antibiotics.

3. Comparison of Antibacterial Activity

Tildipirosin is known for its targeted action against respiratory pathogens, including both Gram-negative bacteria and Mycoplasma species. Compared to other antibiotics, Tildipirosin provides prolonged activity with a single-dose treatment, making it convenient and effective for field use. Its extended action is particularly beneficial in reducing animal handling and stress, a key consideration in intensive farming settings.

4. Application Fields

Tildipirosin is extensively used in veterinary medicine for the treatment and prevention of respiratory infections in livestock, especially in cattle and swine. It is particularly useful in managing Bovine Respiratory Disease (BRD) and other respiratory issues that affect productivity in intensive farming environments. Its single-dose effectiveness and long-acting profile make Tildipirosin a preferred choice for respiratory disease management, supporting animal welfare and promoting efficient livestock production.

1. Shelf Life

Tildipirosin has a shelf life of 2 years when stored under recommended conditions. During this period, the product maintains its quality, potency, and stability, ensuring consistent efficacy in veterinary applications.

2. Testing Indicators and Standards

2.1 Appearance

Tildipirosin should appear as a white to off-white crystalline powder. Any deviation from this appearance may indicate potential quality issues, serving as an essential quality control parameter.

2.2 Identification

The identity of Tildipirosin is confirmed through analytical methods such as High-Performance Liquid Chromatography (HPLC). These tests verify retention time and other chemical properties to ensure product purity and authenticity.

2.3 pH Value

The pH of a 1% solution of Tildipirosin in water should range between 3.0 and 5.0. Maintaining this pH range is essential for product stability and optimal biological activity in veterinary applications.

2.4 Specific Absorbance

At 280 nm, the specific absorbance of Tildipirosin should meet the required range to confirm product purity and alignment with quality standards.

2.5 Light Absorbing Impurities

Impurities that absorb light at 400 nm should be controlled within specified limits. Managing these impurities helps ensure Tildipirosin’s stability and consistent performance in veterinary use.

2.6 Related Substances Content

Strict limits are set for related substances, with total impurities not exceeding 1.0%. This control ensures high purity and efficacy of Tildipirosin in treating respiratory infections in livestock.

2.7 Heavy Metals Content

The heavy metals content in Tildipirosin should not exceed 10 ppm. Keeping heavy metal levels low is essential for product safety, minimizing potential risks to animal health.

2.8 Water Content

Water content should be controlled between 0.5% and 1.5%. Proper moisture levels help preserve the stability and quality of Tildipirosin, preventing degradation over time.

2.9 Residue on Ignition (Ash Content)

The ash content, or residue on ignition, should not exceed 0.2%. Low ash levels indicate high product purity, free from unwanted inorganic contaminants.

2.10 Content Determination

The active content of Tildipirosin should fall between 98.0% and 102.0%. Meeting this specification ensures the product’s effectiveness in veterinary treatments, providing reliable antibacterial action.

1. Packaging

Tildipirosin is securely packaged in fiber drums, available in two standard sizes: 15 kg/drum and 25 kg/drum. This packaging safeguards the product from environmental factors like moisture, light, and oxidation, ensuring the stability and quality of Tildipirosin during storage and transportation. The fiber drums are designed for easy handling, simplifying logistics and facilitating efficient inventory management.

2. Transportation Modes

2.1 Express Shipping

For smaller or urgent orders, we offer express shipping through reputable international carriers, including DHL, TNT, and FedEx. These reliable carriers provide quick delivery to meet urgent customer needs while maintaining product integrity throughout transit.

2.2 Air and Sea Freight

For bulk orders, we provide both air and sea freight options to accommodate varying customer requirements. Air freight offers a faster delivery option for large quantities, although it may involve higher costs. Sea freight is a more economical choice for larger shipments but requires a longer transit time. Customers can choose the transportation method that best fits their order size, budget, and delivery schedule.

3. Delivery Time

Upon receiving payment, Tildipirosin orders are typically processed and shipped within 2–3 business days. This quick turnaround enables us to meet urgent customer demands, enhancing customer satisfaction and reinforcing trust in our reliable and timely service.

Q1: How can I place an order for Tildipirosin?

A: You can place an order by contacting our customer service team directly. Here’s how to reach us:

• WeChat: +86-18663729963, +86-13589106478

• Skype: sunnylee886

• Email: maggie@hope-biotech.com, sunny@hope-biotech.com

• Mobile: +86-18663729963, +86-13589106478

Our team will assist you promptly with the ordering process and answer any questions you may have.

Q2: What is the minimum order quantity (MOQ) for Tildipirosin?

A: Our standard MOQ for Tildipirosin is 0.5 kg. However, if you require a specific quantity, please reach out to us, and we will do our best to accommodate your needs.

Q3: What certifications does your company have for Tildipirosin?

A: Our production facility is certified with GMP and ISO 9001 standards, ensuring rigorous quality control and manufacturing excellence. We also hold FSC and CEP certifications, demonstrating our commitment to producing Tildipirosin at the highest industry standards for quality, safety, and reliability.

Q4: What is Tildipirosin used for?

A: Tildipirosin is a macrolide antibiotic widely used in veterinary medicine, primarily for treating respiratory infections in cattle and swine. It is highly effective against respiratory pathogens such as Mannheimia haemolytica, Pasteurella multocida, and Histophilus somni, making it an essential choice for managing bovine respiratory disease (BRD) and other respiratory infections in livestock.

Q5: How does Tildipirosin work?

A: Tildipirosin works by inhibiting bacterial protein synthesis. It binds to the 50S ribosomal subunit in bacteria, preventing the translation of mRNA and thereby stopping bacterial growth. This mode of action makes it particularly effective against respiratory pathogens in livestock.

Q6: Is Tildipirosin safe for use in animals?

A: Yes, Tildipirosin is safe for use in cattle and swine when administered according to a veterinarian’s instructions. It has been approved for veterinary use and is generally well-tolerated by animals. As with any antibiotic, proper dosage and administration are essential to minimize the risk of side effects and ensure efficacy.

Q7: How should Tildipirosin be stored?

A: Tildipirosin should be stored in a cool, dry place, away from direct sunlight and moisture. Proper storage helps maintain the product’s stability and effectiveness over its shelf life.

Q8: What is the shelf life of Tildipirosin?

A: Tildipirosin has a shelf life of 2 years when stored under recommended conditions. This ensures that the product retains its potency and efficacy throughout its intended use period.

Q9: Can I obtain a Certificate of Analysis (CoA) for Tildipirosin?

A: Yes, we provide a Certificate of Analysis (CoA) for each batch of Tildipirosin. The CoA includes detailed information on purity, potency, and compliance with quality standards. It is available upon request to ensure transparency and guarantee product quality.

Q10: Can Tildipirosin be used alongside other antibiotics?

A: While Tildipirosin is highly effective as a standalone treatment for respiratory infections, combining antibiotics should only be done under veterinary guidance. A veterinarian can determine the best approach based on the specific condition and animal needs.