Florfenicol
CAS: | 73231-34-2 |
Application: | Effective against a wide range of Gram-negative and Gram-positive bacteria, including Pasteurella, Escherichia coli, and Streptococcus species. Florfenicol is commonly used in veterinary medicine to treat respiratory, enteric, and systemic infections in livestock, particularly in cattle, swine, and poultry, enhancing animal health and productivity. |
Appearance: | White to off-white crystalline powder. |
Purity: | ≥98% |
Solubility: | Sparingly soluble in water; freely soluble in methanol and slightly soluble in ethanol. |
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Product Description
Florfenicol is a broad-spectrum antibiotic widely used in veterinary medicine for its effectiveness against both Gram-negative and Gram-positive bacteria, including Pasteurella, Escherichia coli, and Streptococcus species. It is commonly applied in the treatment of respiratory, enteric, and systemic infections in livestock, particularly in cattle, swine, and poultry, supporting animal health and improving productivity in intensive farming environments.
1. Name and Synonyms
The product is officially named Florfenicol, and is sometimes referred to as Fluorinated Thiamphenicol in certain veterinary settings. This name is widely recognized in clinical and research environments, ensuring ease of identification across various applications in animal health.
2. Chemical Identification
Florfenicol is identified with the CAS number 73231-34-2, serving as a unique identifier in pharmaceutical and veterinary fields. This CAS number ensures accuracy in research, production, and quality control processes.
3. Appearance and Physical Properties
Florfenicol typically appears as a white to off-white crystalline powder. This visual characteristic supports product identification and quality control throughout the manufacturing and distribution process.
4. Purity and Solubility
Florfenicol has a high purity level of ≥ 98%, ensuring effective results in veterinary applications. It is sparingly soluble in water, more soluble in methanol, and slightly soluble in ethanol, which allows for versatile formulation options in veterinary treatments for livestock and poultry.
5. Molecular Structure
The molecular formula of Florfenicol is C₁₂H₁₄Cl₂FNO₄S with a molecular weight of approximately 358.2 g/mol. This structure enables its unique mechanism of action, effectively inhibiting bacterial protein synthesis, which makes it a potent choice for controlling a range of bacterial infections in livestock.
1. Antibiotic Type
Florfenicol belongs to the amphenicol class of antibiotics. Amphenicols are broad-spectrum antibiotics effective against a wide range of Gram-negative and Gram-positive bacteria. Florfenicol inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, blocking peptide bond formation and halting bacterial growth. This mechanism makes Florfenicol effective for treating a variety of infections in livestock, particularly respiratory and systemic infections.
2. Antibacterial Spectrum
2.1 Gram-Negative Bacteria
Florfenicol is highly effective against a variety of Gram-negative bacteria, including Pasteurella multocida, Escherichia coli, Salmonella spp., and Haemophilus spp. These pathogens are known to cause respiratory and enteric infections in animals, particularly in cattle, swine, and poultry. Florfenicol’s broad effectiveness against these bacteria makes it a valuable choice for treating respiratory, gastrointestinal, and systemic infections in livestock.
2.2 Gram-Positive Bacteria
Florfenicol also exhibits activity against some Gram-positive bacteria, such as Streptococcus spp. and Staphylococcus aureus. Streptococcus species are associated with respiratory and systemic infections, while Staphylococcus aureus can lead to skin and soft tissue infections. Florfenicol’s broad-spectrum activity makes it suitable for treating mixed infections, providing comprehensive management of bacterial diseases in animals.
2.3 Other Microorganisms
In addition to its broad-spectrum antibacterial effects, Florfenicol is active against certain mycoplasmas, such as Mycoplasma bovis and Mycoplasma hyopneumoniae, which are common respiratory pathogens in cattle and swine. This activity against mycoplasmas expands Florfenicol’s use in treating respiratory diseases in livestock, especially where both Gram-negative bacteria and mycoplasmas are involved.
3. Comparison of Antibacterial Activity
Florfenicol is notable for its enhanced tissue penetration and broad-spectrum activity, making it effective in controlling systemic and respiratory infections. Compared to older antibiotics, Florfenicol provides rapid and potent bacterial inhibition, making it a valuable option for situations where fast and comprehensive treatment is needed. Its efficacy against both Gram-negative bacteria and mycoplasmas also offers an advantage over other antibiotics with narrower spectrums.
4. Application Fields
Florfenicol is widely used in veterinary medicine, particularly for the treatment of respiratory, enteric, and systemic infections in animals, including cattle, swine, and poultry. It is highly effective in managing bacterial outbreaks that threaten animal health and productivity, making it essential for disease prevention and control in intensive farming. Due to its broad-spectrum antibacterial properties, Florfenicol is an ideal choice for preventing and treating infections in animal husbandry, ensuring animal welfare and maintaining productivity in livestock operations.
1. Shelf Life
Florfenicol has a shelf life of 2 years when stored under recommended conditions. During this period, the product maintains its quality, effectiveness, and stability, ensuring it delivers the intended antibacterial effects in veterinary use.
2. Testing Indicators and Standards
2.1 Appearance
Florfenicol should appear as a white to off-white crystalline powder. Any deviation from this appearance may indicate potential quality issues and serves as a fundamental quality control measure.
2.2 Identification
The product is identified through various analytical methods, including High-Performance Liquid Chromatography (HPLC), which uses retention time (tR) to confirm the identity of Florfenicol. Additional chemical tests ensure its purity and authenticity, verifying product quality from multiple perspectives.
2.3 pH Value
The pH of a 1% solution of Florfenicol in water should range between 4.5 and 6.5. Maintaining this pH range is crucial for product stability and biological activity, as deviations could affect the product’s effectiveness.
2.4 Specific Absorbance
At 223 nm, the specific absorbance of Florfenicol should meet the required range to ensure quality. This measurement confirms product purity and verifies alignment with the expected absorbance profile.
2.5 Light Absorbing Impurities
At 420 nm, light-absorbing impurities should not exceed specified limits. Controlling these impurities helps maintain product stability and ensures Florfenicol remains effective in veterinary applications.
2.6 Related Substances Content
Strict limits are set for related substances to ensure high purity. Impurities, including structurally related amphenicol compounds, must be kept below 0.5% to uphold product quality and ensure its efficacy in treating infections.
2.7 Heavy Metals Content
The heavy metals content in Florfenicol should not exceed 10 ppm. Low levels of heavy metals are essential for product safety, minimizing the risk of adverse effects on animal health.
2.8 Water Content
Water content should be controlled between 0.5% and 1.5%. Excess moisture can impact the stability and quality of Florfenicol, so maintaining it within this range ensures product consistency and prevents degradation.
2.9 Residue on Ignition (Ash Content)
The residue on ignition, or ash content, should not exceed 0.1%. This low ash content indicates high product purity, free from unwanted inorganic contaminants.
2.10 Content Determination
The potency of Florfenicol is determined based on its active content, which should range between 98.0% and 102.0%. Ensuring the active content meets this specification guarantees the product’s effectiveness in veterinary applications, providing reliable antibacterial action.
1. Packaging
Florfenicol is packaged in fiber drums, available in two sizes: 15 kg/drum and 25 kg/drum. This packaging method provides strong protection against environmental factors such as moisture, light, and oxidation, preserving the product’s stability during storage and transportation. The fiber drums are also designed for ease of handling, simplifying logistics and inventory management.
2. Transportation Modes
2.1 Express Shipping
For smaller or urgent orders, we offer express shipping via reputable international carriers, including DHL, TNT, FedEx, and other trusted providers. These options ensure fast and reliable delivery, meeting the time-sensitive needs of our customers.
2.2 Air and Sea Freight
For bulk orders, air or sea freight is available. Air freight offers a faster delivery option for larger quantities but may come at a higher cost. Sea freight is more economical for bulk shipments but has a longer transit time. Customers can choose the transportation method that best suits their needs, considering the order size and urgency.
3. Delivery Time
After payment is received, Florfenicol orders are typically processed and shipped within 2–3 business days. This prompt delivery helps fulfill urgent customer needs, enhancing customer satisfaction and trust in our dependable service.
1. GMP Compliance
Our facility operates in full compliance with Good Manufacturing Practice (GMP) standards, ensuring high-quality production processes and consistent product quality for Erythromycin Thiocyanate. This certification guarantees that each batch meets stringent industry standards for safety and efficacy.
2. ISO Certification
Shandong Hope Biotech holds an ISO 9001 certification, reflecting our dedication to quality management and continuous improvement. This certification demonstrates our commitment to maintaining high standards in the production of veterinary antibiotics, including Erythromycin Thiocyanate.
3. Veterinary Drug Certification
Erythromycin Thiocyanate is manufactured under regulatory approval for veterinary use, meeting all necessary certifications and standards required for antibiotics in animal health. This ensures the product’s safety, quality, and effectiveness when used in livestock and poultry.
4. Third-Party Testing
Each batch of Erythromycin Thiocyanate undergoes independent third-party testing to verify its purity, potency, and safety. We provide Certificates of Analysis (CoA) upon request, offering transparency and reinforcing our commitment to quality assurance for our customers.
5. Environmental and Safety Standards
Our production practices for Erythromycin Thiocyanate adhere to strict environmental and safety regulations. We prioritize responsible manufacturing processes that minimize environmental impact, uphold worker safety, and align with industry-leading sustainability standards.
Q1: How can I place an order for Florfenicol?
A: You can place an order by contacting our online customer service team for immediate assistance. Alternatively, you can reach us via the following methods:
•Wechat: +86-18663729963, +86-13589106478
•Skype: sunnylee886
•Email: maggie@hope-biotech.com, sunny@hope-biotech.com
•Mobile: +86-18663729963, +86-13589106478
Q2: What is the minimum order quantity (MOQ) for Florfenicol?
A: Our MOQ is 0.5 kg. However, if you have specific quantity requirements, feel free to discuss them with us, and we will do our best to accommodate your needs.
Q3: What certifications does your company have for Florfenicol?
A: Our production facility holds certifications including GMP, ISO 9001, FSC, and CEP, confirming our commitment to high-quality and reliable manufacturing practices.
Q4: What is Florfenicol used for?
A: Florfenicol is a broad-spectrum antibiotic commonly used in veterinary medicine to treat respiratory, enteric, and systemic infections in livestock, including cattle, swine, and poultry. It is effective against a range of Gram-negative and Gram-positive bacteria, making it valuable in intensive farming for maintaining animal health and productivity.
Q5: Is Florfenicol safe for use in animals?
A: Yes, when administered under the guidance of a licensed veterinarian, Florfenicol is safe and effective for treating bacterial infections in animals. Adhering to proper dosage instructions helps ensure the best therapeutic outcomes while minimizing potential side effects.
Q6: How does Florfenicol work?
A: Florfenicol inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, which blocks peptide bond formation and halts bacterial growth. This mechanism makes it effective against both Gram-negative and Gram-positive bacteria, as well as certain mycoplasmas.
Q7: Can Florfenicol be used for both poultry and livestock?
A: Yes, Florfenicol is suitable for use in various types of livestock, including poultry, cattle, and swine. Its broad-spectrum activity makes it valuable for treating infections across different animal species.
Q8: How should Florfenicol be stored?
A: Store Florfenicol in a cool, dry place away from light and moisture to maintain its stability and effectiveness. Proper storage conditions help ensure that the product retains its quality throughout its shelf life.
Q9: What is the recommended dosage of Florfenicol for animals?
A: The dosage varies depending on the type of animal, the severity of the infection, and veterinary guidance. We recommend consulting a licensed veterinarian to determine the appropriate dosage for specific cases.
Q10: Can I get a Certificate of Analysis (CoA) for Florfenicol?
A: Yes, we provide a Certificate of Analysis (CoA) for each batch of Florfenicol. The CoA includes detailed information on purity, potency, and compliance with quality standards, available upon request to ensure transparency and product quality assurance.