1. Name and Synonyms

The product is officially named Ampicillin Trihydrate and is widely recognized under this name across veterinary and medical contexts. This standardized naming ensures accurate identification for various therapeutic applications in treating bacterial infections.

2. Chemical Identification

Ampicillin Trihydrate is identified by the CAS number 7177-48-2, which serves as a unique identifier within the pharmaceutical industry. This CAS number aids in precise tracking for research, production, and quality control processes.

3. Appearance and Physical Properties

Ampicillin Trihydrate typically appears as a white to off-white crystalline powder. This distinct appearance supports product identification and quality control during manufacturing and distribution.

4. Purity and Solubility

Ampicillin Trihydrate has a high purity level of ≥98%, ensuring consistent and reliable efficacy in veterinary and medical applications. It is sparingly soluble in water and more soluble in alkaline solutions, which supports flexibility in various formulations, including oral and injectable solutions.

5. Molecular Structure

The molecular formula of Ampicillin Trihydrate is C₁₆H₁₉N₃O₄S·3H₂O, with a molecular weight of approximately 403.45 g/mol. Its chemical structure enables it to inhibit bacterial cell wall synthesis by targeting penicillin-binding proteins, effectively eliminating susceptible bacteria and providing broad-spectrum activity against Gram-positive and certain Gram-negative bacteria.

1. Type and Mechanism of Action

Ampicillin Trihydrate is a broad-spectrum beta-lactam antibiotic in the penicillin class, commonly used in both human and veterinary medicine to treat bacterial infections. Ampicillin works by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) within the bacterial cell wall, preventing the formation of cross-links in peptidoglycan, an essential component of the cell wall. This mechanism disrupts cell wall integrity, ultimately leading to bacterial cell lysis and death, making Ampicillin highly effective against susceptible Gram-positive and certain Gram-negative bacteria.

2. Spectrum of Activity

2.1 Gram-Positive Bacteria

Ampicillin Trihydrate is highly effective against a wide range of Gram-positive bacteria, including Streptococcus species, Staphylococcus aureus (non-beta-lactamase-producing strains), and Enterococcus species. Its efficacy in combating Gram-positive pathogens makes it a preferred choice for infections in livestock and companion animals, such as respiratory and urinary tract infections.

2.2 Gram-Negative Bacteria

Ampicillin also exhibits activity against specific Gram-negative bacteria, including Escherichia coli, Haemophilus influenzae, and Proteus mirabilis. Its effectiveness against these pathogens supports its use in treating gastrointestinal and respiratory infections in animals, especially where mixed infections of Gram-positive and Gram-negative bacteria are present.

3. Comparison of Antibacterial Activity

Ampicillin Trihydrate is recognized for its broad-spectrum antibacterial activity and its ability to effectively target both Gram-positive and certain Gram-negative bacteria. Compared to other antibiotics, its beta-lactam structure provides high efficacy with a relatively low risk of toxicity, making it a safe and effective option in veterinary medicine. Ampicillin’s well-tolerated profile, combined with its potent antibacterial action, makes it a reliable choice in treating various bacterial infections in livestock and companion animals.

4. Application Fields

Ampicillin Trihydrate is widely used in veterinary medicine to treat a range of bacterial infections in livestock and companion animals.

•Veterinary Use: Ampicillin Trihydrate is used for the treatment of bacterial infections in animals, particularly respiratory, urinary, and gastrointestinal infections. It is commonly administered to cattle, swine, sheep, and poultry to control bacterial infections that can impact health and productivity. In small animals, it is used for managing infections in the respiratory and urinary tracts.

•Broad-Spectrum Control: Due to its broad-spectrum efficacy, Ampicillin Trihydrate is suitable for use in both farm and companion animals, where bacterial infections are prevalent. It is especially beneficial in settings where mixed bacterial infections may occur, helping to maintain animal health and supporting growth and production in livestock.

1. Shelf Life

Ampicillin Trihydrate has a shelf life of 2 years when stored under recommended conditions. During this period, the product retains its quality, potency, and stability, ensuring reliable efficacy in veterinary and pharmaceutical applications for treating bacterial infections.

2. Testing Indicators and Standards

2.1 Appearance

Ampicillin Trihydrate should appear as a white to off-white crystalline powder. Any noticeable deviation from this appearance may indicate potential quality issues, serving as an important quality control measure.

2.2 Identification

The identity of Ampicillin Trihydrate is confirmed through analytical methods such as High-Performance Liquid Chromatography (HPLC). These tests verify retention time and other chemical properties, ensuring product purity and authenticity.

2.3 pH Value

The pH of a 1% solution of Ampicillin Trihydrate in water should be within the specified range according to product standards. Maintaining the appropriate pH range is essential for product stability and optimal biological activity in applications.

2.4 Specific Absorbance

At 325 nm, the specific absorbance of Ampicillin Trihydrate should fall within the required range to confirm product purity and compliance with quality standards.

2.5 Light Absorbing Impurities

Impurities that absorb light at 400 nm should be controlled within specified limits to ensure stability. Managing these impurities helps maintain Ampicillin Trihydrate’s efficacy in applications over time.

2.6 Related Substances Content

Strict limits are set for related substances, with total impurities not exceeding 1.0%. This control ensures high purity and effectiveness, supporting reliable performance of Ampicillin Trihydrate in treating bacterial infections.

2.7 Heavy Metals Content

The heavy metals content in Ampicillin Trihydrate should not exceed 20 ppm. Maintaining low heavy metal levels is essential for product safety, minimizing risks in pharmaceutical and veterinary applications.

2.8 Water Content

Water content should be controlled between 10.0% and 15.0%. Proper moisture levels are crucial for preserving the stability and quality of Ampicillin Trihydrate, preventing degradation during storage.

2.9 Residue on Ignition (Ash Content)

The ash content, or residue on ignition, should not exceed 0.2%. Low ash levels reflect high product purity, indicating minimal unwanted inorganic contaminants.

2.10 Content Determination

The active content of Ampicillin Trihydrate should fall between 90.0% and 100.5%. Meeting this specification ensures consistent effectiveness in treatments, providing reliable antibacterial action in both human and veterinary applications.

1. Packaging

Ampicillin Trihydrate is securely packaged in fiber drums, available in standard sizes of 15 kg/drum and 25 kg/drum. This packaging protects the product from environmental factors such as moisture, light, and oxidation, ensuring the stability and quality of Ampicillin Trihydrate during storage and transportation. The fiber drums are designed for easy handling, optimizing logistics and making inventory management more efficient.

2. Transportation Modes

2.1 Express Shipping

For smaller or urgent orders, we offer express shipping through reputable international carriers, including DHL, TNT, and FedEx. These trusted carriers provide fast delivery to meet urgent customer needs while maintaining product integrity throughout transit.

2.2 Air and Sea Freight

For bulk orders, we provide both air and sea freight options to accommodate different customer requirements. Air freight offers a quicker delivery option for larger quantities, though it may involve higher costs. Sea freight is a more economical choice for larger shipments but requires a longer transit time. Customers can select the transportation method that best aligns with their order size, budget, and delivery schedule.

3. Delivery Time

Once payment is received, Ampicillin Trihydrate orders are typically processed and dispatched within 2–3 business days. This quick turnaround allows us to meet urgent customer demands, enhancing customer satisfaction and reinforcing trust in our reliable and efficient service.

Q1: How can I place an order for Ampicillin Trihydrate?

A: To place an order, please contact our customer service team directly using any of the following methods:

•WeChat: +86-18663729963, +86-13589106478

•Skype: sunnylee886

•Email: maggie@hope-biotech.com, sunny@hope-biotech.com

•Mobile: +86-18663729963, +86-13589106478

Our team is available to assist with the ordering process and to answer any questions you may have about our Ampicillin Trihydrate products.

Q2: What is the minimum order quantity (MOQ) for Ampicillin Trihydrate?

A: Our standard MOQ for Ampicillin Trihydrate is 1 kg. However, if you require a different quantity, please reach out to us, and we will do our best to accommodate your specific needs.

Q3: What certifications does your company hold for Ampicillin Trihydrate?

A: Our production facility is certified with GMP (Good Manufacturing Practice) and ISO 9001 standards, ensuring strict quality control and high manufacturing standards. These certifications demonstrate our commitment to producing Ampicillin Trihydrate with the highest standards for quality, safety, and reliability in pharmaceutical and veterinary applications.

Q4: What is the recommended storage condition for Ampicillin Trihydrate?

A: Ampicillin Trihydrate should be stored in a cool, dry place, away from direct sunlight and moisture to maintain its potency and stability. Recommended storage conditions are generally at room temperature, not exceeding 25°C, and in tightly sealed packaging.

Q5: Is Ampicillin Trihydrate effective against both Gram-positive and Gram-negative bacteria?

A: Yes, Ampicillin Trihydrate is a broad-spectrum antibiotic effective against a variety of Gram-positive and Gram-negative bacteria. It is commonly used to treat infections caused by bacteria such as Streptococcus, Staphylococcus, Escherichia coli, Salmonella, and Proteus species in both humans and animals.

Q6: What applications is Ampicillin Trihydrate commonly used for?

A: Ampicillin Trihydrate is widely used in both human and veterinary medicine to treat bacterial infections. It is effective for respiratory, gastrointestinal, urinary tract, and skin infections. In veterinary applications, it is commonly used for treating infections in livestock, poultry, and pets, enhancing overall health and productivity.

Q7: How does Ampicillin Trihydrate work?

A: Ampicillin Trihydrate works by inhibiting bacterial cell wall synthesis, leading to cell lysis and death of the bacteria. Its bactericidal action is particularly effective in actively dividing bacterial cells, making it suitable for a range of infections.

Q8: Does your Ampicillin Trihydrate undergo third-party testing?

A: Yes, each batch of Ampicillin Trihydrate undergoes independent third-party testing to verify its purity, potency, and safety. We provide a Certificate of Analysis (CoA) upon request, ensuring transparency and confirming our commitment to quality assurance.

Q9: Can I use Ampicillin Trihydrate for long-term treatment?

A: The duration of treatment with Ampicillin Trihydrate should always be determined by a qualified veterinarian or healthcare provider, as long-term use may require specific monitoring for efficacy and potential resistance development. It’s essential to follow professional guidelines to ensure optimal results.