1. Name and Synonyms

The product is officially named Milbemycin Oxime and is widely recognized under this name in veterinary and pharmaceutical contexts. This standardized name ensures accurate identification in various therapeutic and pharmaceutical applications.

2. Chemical Identification

Milbemycin Oxime is identified by the CAS number 129496-10-2, serving as a unique identifier within veterinary and pharmaceutical industries. This CAS number allows for precise tracking in research, production, and quality control processes.

3. Appearance and Physical Properties

Milbemycin Oxime typically appears as a white to off-white crystalline powder. This visual characteristic aids in product identification and quality control during manufacturing and distribution.

4. Purity and Solubility

Milbemycin Oxime has a high purity level of ≥98%, ensuring reliable performance in veterinary applications. It is practically insoluble in water but soluble in organic solvents such as ethanol and acetone, allowing for convenient formulation in tablets, chewable forms, and other oral solutions for pets.

5. Molecular Structure

The molecular formula of Milbemycin Oxime is C₃₂H₄₅NO₇, with a molecular weight of approximately 555.7 g/mol. This chemical structure enables Milbemycin Oxime to disrupt nerve transmission in parasites, leading to paralysis and death of the parasites, thereby effectively managing a range of parasitic infections in companion animals.

1. Antiparasitic Type

Milbemycin Oxime is a macrocyclic lactone antiparasitic agent commonly used in veterinary medicine to control a broad range of parasites in companion animals, particularly dogs and cats. It works by interfering with nerve transmission in parasites, leading to paralysis and death. This targeted mechanism makes Milbemycin Oxime highly effective for treating internal parasites, such as heartworms, roundworms, and hookworms, as well as external parasites like mites. Its selective action ensures minimal impact on the host animal, making it a safe and reliable choice for parasite control in pets.

2. Spectrum of Activity

2.1 Nematodes (Roundworms and Hookworms)

Milbemycin Oxime is effective against various nematode parasites, including species of roundworms (e.g., Toxocara canis and Toxascaris leonina) and hookworms (e.g., Ancylostoma caninum and Uncinaria stenocephala). These parasites commonly infest dogs and cats, leading to gastrointestinal issues, anemia, and other health problems. Milbemycin Oxime’s efficacy against nematodes makes it an essential component of comprehensive parasite control programs for pets.

2.2 Heartworms

Milbemycin Oxime is highly effective in preventing heartworm disease, caused by Dirofilaria immitis. It works as a preventive by killing the heartworm larvae (microfilariae) before they mature into adults. Heartworm prevention is critical for canine and feline health, particularly in areas where heartworm prevalence is high, as untreated infections can be life-threatening.

2.3 Mites (External Parasites)

Milbemycin Oxime is also effective against certain mite species, such as those that cause demodectic mange (Demodex canis) in dogs. This efficacy against mites provides a valuable option for managing skin conditions associated with mite infestations, improving pet welfare and skin health.

3. Comparison of Antiparasitic Activity

Milbemycin Oxime is known for its broad-spectrum antiparasitic effects, covering both internal and certain external parasites in pets. Compared to other antiparasitic agents, Milbemycin Oxime offers long-acting protection, reducing the frequency of required doses. Its extended duration of activity makes it ideal for routine monthly prevention of parasites, simplifying treatment schedules for pet owners. Additionally, Milbemycin Oxime’s specificity for parasites minimizes adverse effects, supporting animal safety and comfort.

4. Application Fields

Milbemycin Oxime is widely used in veterinary medicine for the prevention and treatment of various parasitic infections in pets, primarily dogs and cats.

•Routine Parasite Prevention: Milbemycin Oxime is often used as a monthly preventive treatment for heartworms, roundworms, and hookworms in dogs and cats. Regular dosing protects against life-threatening infections, supporting long-term pet health.

•Treatment of Mite Infestations: Milbemycin Oxime is effective in treating demodectic mange in dogs, helping control skin infections caused by mites and improving coat and skin health.

Milbemycin Oxime’s broad-spectrum efficacy, safety, and ease of use make it a top choice for parasite prevention and treatment in companion animals. Its ability to prevent multiple types of parasites with a single monthly dose provides convenience for pet owners while ensuring comprehensive parasite control.

1. Shelf Life

Milbemycin Oxime has a shelf life of 2 years when stored under recommended conditions. During this period, the product retains its quality, potency, and stability, ensuring reliable efficacy in veterinary applications for controlling parasites.

2. Testing Indicators and Standards

2.1 Appearance

Milbemycin Oxime should appear as a white to slightly off-white crystalline powder. Any noticeable deviation from this appearance may indicate potential quality issues, serving as an important quality control measure.

2.2 Identification

The identity of Milbemycin Oxime is confirmed through analytical methods such as High-Performance Liquid Chromatography (HPLC) and Infrared Spectroscopy (IR). These tests verify retention time and other chemical properties to ensure product purity and authenticity.

2.3 pH Value

The pH of a 1% solution of Milbemycin Oxime in water should be within the specified range, as determined by product standards. Maintaining this pH range is essential for product stability and optimal biological activity in veterinary applications.

2.4 Specific Absorbance

At a specified wavelength, the specific absorbance of Milbemycin Oxime should fall within the required range, confirming product purity and compliance with quality standards.

2.5 Light Absorbing Impurities

Impurities that absorb light at 400 nm should be controlled within specified limits to ensure stability. Managing these impurities helps maintain Milbemycin Oxime’s consistent efficacy in veterinary use.

2.6 Related Substances Content

Strict limits are set for related substances, with total impurities not exceeding 1.0%. This control ensures high purity and effectiveness of Milbemycin Oxime in treating parasitic infections.

2.7 Heavy Metals Content

The heavy metals content in Milbemycin Oxime should not exceed 10 ppm. Keeping heavy metal levels low is essential for product safety, minimizing potential risks to animal health.

2.8 Water Content

Water content should be controlled between 0.5% and 1.5%. Proper moisture levels are crucial to preserving the stability and quality of Milbemycin Oxime, preventing degradation over time.

2.9 Residue on Ignition (Ash Content)

The ash content, or residue on ignition, should not exceed 0.2%. Low ash levels reflect high product purity, indicating minimal unwanted inorganic contaminants.

2.10 Content Determination

The active content of Milbemycin Oxime should fall between 98.0% and 102.0%. Meeting this specification ensures consistent effectiveness in veterinary treatments, providing reliable antiparasitic action against a wide range of internal and external parasites in pets and livestock.

1. Packaging

Milbemycin Oxime is securely packaged in fiber drums, available in standard sizes of 15 kg/drum and 25 kg/drum. This packaging protects the product from environmental factors such as moisture, light, and oxidation, ensuring the stability and quality of Milbemycin Oxime during storage and transportation. The fiber drums are designed for easy handling, optimizing logistics and facilitating efficient inventory management.

2. Transportation Modes

2.1 Express Shipping

For smaller or urgent orders, we offer express shipping through reputable international carriers, including DHL, TNT, and FedEx. These trusted carriers provide rapid delivery to meet urgent customer needs while preserving product integrity throughout transit.

2.2 Air and Sea Freight

For bulk orders, we offer both air and sea freight options to accommodate various customer needs. Air freight ensures quicker delivery for large quantities but may involve higher costs. Sea freight is a more economical choice for larger shipments, although it requires a longer transit time. Customers can select the transportation method that best aligns with their order size, budget, and delivery timeline.

3. Delivery Time

Once payment is received, Milbemycin Oxime orders are typically processed and dispatched within 2–3 business days. This swift turnaround allows us to meet urgent customer demands, enhancing customer satisfaction and reinforcing trust in our reliable and efficient service.

Q1: How can I place an order for Milbemycin Oxime?

A: To place an order, please contact our customer service team using any of the following methods:

•WeChat: +86-18663729963, +86-13589106478

•Skype: sunnylee886

•Email: maggie@hope-biotech.com, sunny@hope-biotech.com

•Mobile: +86-18663729963, +86-13589106478

Our team is available to guide you through the ordering process and address any questions you may have.

Q2: What is the minimum order quantity (MOQ) for Milbemycin Oxime?

A: Our standard MOQ for Milbemycin Oxime is 1 kg. However, if you need a different quantity, please contact us, and we will work to accommodate your specific needs.

Q3: What certifications does your company hold for Milbemycin Oxime?

A: Our production facility is certified with GMP and ISO 9001 standards, ensuring rigorous quality control and manufacturing practices. These certifications affirm our commitment to delivering high-quality Milbemycin Oxime that meets global veterinary and pharmaceutical requirements.

Q4: What are the primary applications of Milbemycin Oxime?

A: Milbemycin Oxime is commonly used as an antiparasitic agent in veterinary medicine, especially for controlling parasites such as roundworms, hookworms, and heartworms in dogs and cats. It is also effective against certain external parasites, offering comprehensive parasite protection for pets.

Q5: How should Milbemycin Oxime be stored?

A: Milbemycin Oxime should be stored in a cool, dry place, away from direct sunlight and moisture. Proper storage conditions help maintain the product’s stability, potency, and efficacy over time.

Q6: What is the shelf life of Milbemycin Oxime?

A: Milbemycin Oxime has a shelf life of approximately 2 years when stored under recommended conditions. Regular quality checks ensure that the product remains effective throughout its shelf life.

Q7: Is Milbemycin Oxime safe for all animals?

A: Milbemycin Oxime is safe for use in dogs and cats when administered according to recommended dosages. However, certain dog breeds, particularly those with a genetic sensitivity to macrocyclic lactones (such as Collies), may be more susceptible to adverse effects. Consult with a veterinarian before administering Milbemycin Oxime to ensure safe and effective use.