1. Name and Synonyms

The product is officially named Ceftiofur Sodium, also known by synonyms such as Ceftiofur Sodium Salt and Sodium Ceftiofur. These alternate names are used in different research and clinical settings, offering clarity for diverse applications in veterinary medicine.

2. Chemical Identification

Ceftiofur Sodium is identified with the CAS number 104010-37-9, serving as a unique identifier in the chemical and pharmaceutical industries. This ensures precision in research, production, and quality control.

3. Appearance and Physical Properties

Ceftiofur Sodium appears as an off-white to pale yellow powder. This physical characteristic aids in the identification and quality inspection of the product during manufacturing and distribution.

4. Purity and Solubility

The product meets a high purity standard of ≥ 98% (HPLC), ensuring optimal effectiveness and stability during application. Ceftiofur Sodium is highly soluble in water and exhibits limited solubility in methanol, enabling convenient preparation in veterinary practices. It is insoluble in most organic solvents, supporting its targeted usage in aqueous formulations.

5. Molecular Structure

The molecular formula of Ceftiofur Sodium is C₁₉H₁₆N₅NaO₇S₃, with a molecular weight of 545.54 g/mol. This molecular structure is central to its antibiotic function, influencing the mechanism of action that makes it effective against bacterial infections in livestock.

1. Antibiotic Type

Ceftiofur Sodium belongs to the cephalosporin class of antibiotics. Cephalosporin antibiotics are widely used in veterinary medicine due to their broad-spectrum antibacterial properties. They work by inhibiting bacterial cell wall synthesis, leading to the elimination of various bacterial pathogens that cause infections in livestock.

2. Antibacterial Spectrum

2.1 Gram-Positive Bacteria

Ceftiofur Sodium is effective against a range of Gram-positive bacteria, including Streptococcus spp., Staphylococcus aureus, and Corynebacterium spp. These pathogens are known to cause respiratory infections, skin infections, and other bacterial diseases in animals. By inhibiting these bacteria, Ceftiofur Sodium serves as an effective treatment option in controlling related infections in livestock.

2.2 Gram-Negative Bacteria

Ceftiofur Sodium also exhibits strong inhibitory effects on Gram-negative bacteria such as Escherichia coli, Salmonella spp., Pasteurella multocida, Haemophilus spp., and Klebsiella pneumoniae. These bacteria are often associated with respiratory diseases, gastrointestinal infections, and septicemia in animals. The effectiveness of Ceftiofur Sodium against these pathogens enhances its use in treating complex infections in cattle, swine, and poultry.

2.3 Other Microorganisms

In addition to its antibacterial effects, Ceftiofur Sodium also has some activity against other microorganisms commonly found in veterinary contexts, such as Actinobacillus pleuropneumoniae and certain anaerobes. These organisms contribute to various respiratory and systemic infections, especially in swine and cattle, making Ceftiofur Sodium a versatile option for multiple infection types.

3. Comparison of Antibacterial Activity

Ceftiofur Sodium’s antibacterial activity is known to be significantly higher compared to older generations of antibiotics. Its potent activity enables effective inhibition of bacterial growth and replication, resulting in quicker recovery times for animals. The drug’s stability and broad spectrum also reduce the likelihood of resistance development when used appropriately.

4. Application Fields

Ceftiofur Sodium is commonly used in veterinary medicine, especially for treating respiratory diseases in cattle and swine, as well as bacterial infections in poultry. In clinical practice, it is particularly effective for respiratory diseases such as bovine respiratory disease (BRD) and swine respiratory disease (SRD). Additionally, it is often employed in treating infections caused by mixed bacterial flora, providing comprehensive infection control and improving overall treatment outcomes in livestock and poultry farming.

1. Shelf Life

Ceftiofur Sodium has a shelf life of 2 years when stored under recommended conditions. Throughout this period, the product maintains its quality and efficacy, providing reliability and consistency in veterinary applications. Proper storage is essential to ensure that the product performs as intended over its full shelf life.

2. Testing Indicators and Standards

2.1 Appearance

The product is required to appear as an off-white to pale yellow powder. This visual check is a primary quality control indicator, as any deviation in appearance could signal potential quality issues.

2.2 Identification

Multiple identification methods are used to verify Ceftiofur Sodium, including High-Performance Liquid Chromatography (HPLC) to confirm the retention time (tR) specific to the compound. Additional tests, such as sulfuric acid reaction and chloride reaction, help authenticate the product and confirm its purity from different chemical perspectives.

2.3 pH Value

The pH value of a 1% aqueous solution should be between 4.5 and 6.5. Maintaining this pH range is crucial for the stability and biological activity of Ceftiofur Sodium, ensuring it is suitable for veterinary use.

2.4 Specific Absorbance

At a wavelength of 280 nm, the specific absorbance of Ceftiofur Sodium should fall within a specified range. This absorbance requirement helps verify the product’s quality and consistency, providing a quantitative measure of its purity.

2.5 Light Absorbing Impurities

At 420 nm, the level of light-absorbing impurities should not exceed a specified threshold. Limiting these impurities helps improve product stability and ensures the purity and efficacy of Ceftiofur Sodium.

2.6 Related Substances Content

Strict limits are placed on related substances. For example, the content of desfuroylceftiofur, a known impurity, should be no more than 2.0%. Other impurities, such as cephalosporin-related compounds, are also regulated to ensure that Ceftiofur Sodium maintains its antibacterial potency and safety.

2.7 Ethanol Content

Ceftiofur Sodium’s ethanol content should be below the specified limit, ensuring that the final product remains stable and safe for animal use. Ethanol is sometimes present as a residual solvent from the manufacturing process, so monitoring its level is essential.

2.8 Heavy Metals Content

The heavy metals content is limited to ≤ 20 ppm to ensure animal safety. Excessive heavy metals can be harmful, so strict control is implemented to minimize their presence in the product.

2.9 Water Content

Water content should be within 1.0% – 2.5%. Excessive moisture can lead to product degradation or caking, affecting the product’s stability, appearance, and efficacy.

2.10 Sulfated Ash Content

The sulfated ash content is required to be ≤ 0.2%. This measure of inorganic residue helps to confirm the purity of Ceftiofur Sodium, as excessive ash content could indicate contamination with extraneous materials.

2.11 Content Determination

The active Ceftiofur Sodium content (calculated as C₁₉H₁₆N₅NaO₇S₃) should be within the range of 95.0% – 102.0%. This content determination is essential to ensure that the product meets its labeled potency, providing consistent and effective treatment results in veterinary applications.

1. Packaging

Ceftiofur Sodium is securely packaged in fiber drums, available in two standard sizes: 15 kg/drum and 25 kg/drum. This packaging method provides robust protection against environmental factors such as moisture, light, and oxidation, preserving the product’s stability and quality during storage and transportation. Additionally, the fiber drum packaging is convenient for handling and ensures safe storage.

2. Transportation Modes

2.1 Express Transportation

For smaller orders or urgent deliveries, Ceftiofur Sodium can be shipped via international express services such as DHL, TNT, and FedEx. These well-known couriers offer reliable and fast delivery, ensuring that customers receive their orders within a short time frame.

2.2 Air and Sea Transportation

For bulk shipments, customers can opt for air or sea freight. Air transportation offers faster delivery for large quantities but is relatively more expensive, while sea transportation is a cost-effective option, albeit with a longer transit time. We can assist customers in selecting the most suitable transportation mode based on their specific needs and the quantity ordered.

3. Delivery Time

Upon receiving payment, Ceftiofur Sodium orders are dispatched within 2–3 business days. This prompt processing and delivery timeline enables us to meet urgent client needs and ensure high levels of customer satisfaction.

1. What is Ceftiofur Sodium used for?

Ceftiofur Sodium is a broad-spectrum cephalosporin antibiotic primarily used in veterinary medicine to treat bacterial infections in livestock, particularly respiratory diseases in cattle, swine, and poultry.

2. What is the minimum order quantity (MOQ) for Ceftiofur Sodium?

Our MOQ is 0.5 kg, though we can accommodate custom quantities based on client needs. For more details, please contact us directly.

3. How can I place an order for Ceftiofur Sodium?

You can place an order through our website, or by contacting us via online chat, WeChat, Skype, or email. Our team is ready to assist with your order requirements.

4. What certifications does Shandong Hope Biotech hold for Ceftiofur Sodium?

Our production of Ceftiofur Sodium complies with GMP and ISO 9001 standards. Additionally, we hold FSC and CEP certifications, ensuring quality, safety, and compliance with international standards.

5. What are the available packaging options?

Ceftiofur Sodium is packaged in secure fiber drums, with standard sizes of 15 kg and 25 kg per drum. This packaging provides excellent protection against environmental factors such as moisture and oxidation.

6. What is the shelf life of Ceftiofur Sodium?

The shelf life is 2 years when stored under recommended conditions (cool, dry place, protected from light). Proper storage is essential for maintaining the product’s quality and effectiveness.

7. How long does it take to receive my order?

After payment confirmation, we typically dispatch orders within 2-3 business days. For urgent orders, please contact us to discuss express shipping options.

8. How is the quality and purity of Ceftiofur Sodium verified?

Each batch of Ceftiofur Sodium undergoes rigorous quality checks, including third-party testing to ensure compliance with purity, potency, and safety standards. Certificates of Analysis (CoA) are available upon request.

9. What are the recommended storage conditions for Ceftiofur Sodium?

Store Ceftiofur Sodium in a cool, dry place between 2-8°C, away from direct sunlight, to maintain its stability and effectiveness throughout its shelf life.

10. Does Shandong Hope Biotech offer customer support for product usage?

Yes, our team is available to provide guidance on product use and answer any additional questions. Please feel free to reach out to our customer service team for assistance.