1. Name and Synonyms

The product is officially named Tiamulin Fumarate, commonly abbreviated as TMF in veterinary applications. Recognized across clinical and research fields, this name ensures easy identification in various animal health applications.

2. Chemical Identification

Tiamulin Fumarate is identified by the CAS number 55297-95-5, serving as a unique identifier in pharmaceutical and veterinary fields. This CAS number supports precision in research, production, and quality control processes.

3. Appearance and Physical Properties

Tiamulin Fumarate typically appears as a white to off-white crystalline powder. This appearance aids in product identification and quality control during manufacturing and distribution.

4. Purity and Solubility

Tiamulin Fumarate has a high purity level of ≥ 98%, ensuring consistent efficacy in veterinary applications. It is sparingly soluble in water, but freely soluble in methanol and slightly soluble in ethanol, making it suitable for various veterinary formulations, such as feed additives and oral solutions.

5. Molecular Structure

The molecular formula of Tiamulin Fumarate is C₂₈H₄₇NO₄S•C₄H₄O₄, with a molecular weight of approximately 609.8 g/mol. This structure enables it to inhibit bacterial protein synthesis effectively, making it a trusted option for controlling respiratory and enteric infections in livestock.

1. Antibiotic Type

Tiamulin Fumarate is a pleuromutilin antibiotic, specifically targeting certain Gram-positive bacteria, mycoplasmas, and anaerobic bacteria. It works by inhibiting bacterial protein synthesis through binding to the 50S ribosomal subunit, effectively blocking protein production and bacterial replication. This targeted action makes Tiamulin Fumarate particularly useful for managing respiratory and enteric infections in livestock, especially in pigs and poultry.

2. Antibacterial Spectrum

2.1 Gram-Positive Bacteria

Tiamulin Fumarate is effective against a range of Gram-positive bacteria, including Clostridium perfringens and Erysipelothrix rhusiopathiae. These pathogens are commonly associated with enteric and systemic infections in animals. The effectiveness of Tiamulin Fumarate in managing these bacteria makes it a valuable antibiotic for intensive livestock farming.

2.2 Mycoplasmas

Tiamulin Fumarate is highly effective against Mycoplasma species, such as Mycoplasma hyopneumoniae in pigs and Mycoplasma gallisepticum in poultry. These organisms are responsible for chronic respiratory infections, especially in intensive farming settings. Tiamulin Fumarate’s action against Mycoplasma species is one of its main advantages, providing a targeted approach to respiratory disease management in pigs and poultry.

2.3 Anaerobic Bacteria

Tiamulin Fumarate also demonstrates activity against specific anaerobic bacteria, such as Brachyspira species, which cause swine dysentery. This efficacy broadens the range of infections Tiamulin Fumarate can treat, making it a valuable option for addressing both respiratory and enteric infections in livestock.

3. Comparison of Antibacterial Activity

Tiamulin Fumarate stands out for its targeted activity against Mycoplasma, Gram-positive, and certain anaerobic bacteria. Unlike broad-spectrum antibiotics, Tiamulin Fumarate offers specific action, minimizing the impact on beneficial bacteria and reducing the risk of antimicrobial resistance. This targeted approach makes it ideal for use in settings where selective bacterial control is preferred, such as managing respiratory diseases in swine and poultry.

4. Application Fields

Tiamulin Fumarate is extensively used in veterinary medicine for treating respiratory and enteric infections in livestock, particularly in pigs and poultry. It is highly effective in controlling diseases that significantly impact animal health and productivity, such as swine dysentery and chronic respiratory disease. Its targeted action and efficacy make Tiamulin Fumarate a preferred choice for both preventive and therapeutic applications in intensive farming, helping maintain animal welfare and optimize productivity in livestock operations.

1. Shelf Life

Tiamulin Fumarate has a shelf life of 2 years when stored under recommended conditions. During this period, the product maintains its quality, potency, and stability, ensuring consistent efficacy in veterinary applications.

2. Testing Indicators and Standards

2.1 Appearance

Tiamulin Fumarate should appear as a white to off-white crystalline powder. Any deviation from this appearance may indicate potential quality issues and serves as a fundamental quality control measure.

2.2 Identification

The identity of Tiamulin Fumarate is confirmed using High-Performance Liquid Chromatography (HPLC) and other analytical methods. These tests verify retention time and other chemical properties to ensure product purity and authenticity.

2.3 pH Value

The pH of a 1% solution of Tiamulin Fumarate in water should range between 3.5 and 5.5. Maintaining this pH range is essential for product stability and ensuring optimal biological activity.

2.4 Specific Absorbance

At 225 nm, the specific absorbance of Tiamulin Fumarate should meet the required range to confirm product purity and alignment with quality standards.

2.5 Light Absorbing Impurities

Impurities that absorb light at 400 nm should be controlled within specified limits. Managing these impurities helps ensure Tiamulin Fumarate’s stability and consistent performance in veterinary applications.

2.6 Related Substances Content

Strict limits are set for related substances, with total impurities not exceeding 1.0%. This control ensures high purity and efficacy of Tiamulin Fumarate for treating bacterial and mycoplasmal infections in livestock.

2.7 Heavy Metals Content

The heavy metals content in Tiamulin Fumarate should not exceed 10 ppm. Keeping heavy metal levels low is crucial for product safety, minimizing any potential risks to animal health.

2.8 Water Content

The water content should be controlled between 0.5% and 1.5%. Proper moisture levels preserve the stability and quality of Tiamulin Fumarate, preventing degradation over time.

2.9 Residue on Ignition (Ash Content)

The ash content, or residue on ignition, should not exceed 0.2%. A low ash level indicates high product purity, free from unwanted inorganic contaminants.

2.10 Content Determination

The active content of Tiamulin Fumarate should be between 98.0% and 102.0%. Meeting this specification guarantees the product’s effectiveness in veterinary treatments, providing reliable antimicrobial action.

1. Packaging

Tiamulin Fumarate is securely packaged in fiber drums, available in two standard sizes: 15 kg/drum and 25 kg/drum. This packaging protects the product from environmental factors such as moisture, light, and oxidation, ensuring the stability and quality of Tiamulin Fumarate during storage and transportation. The fiber drums are also designed for easy handling, simplifying logistics and facilitating efficient inventory management.

2. Transportation Modes

2.1 Express Shipping

For smaller or urgent orders, we offer express shipping through reputable international carriers, including DHL, TNT, and FedEx. These reliable carriers ensure quick delivery, meeting urgent customer needs while maintaining product integrity throughout transit.

2.2 Air and Sea Freight

For bulk orders, we provide air and sea freight options to meet varying customer needs. Air freight offers a faster delivery option for large quantities, though it may incur higher costs. Sea freight is a more economical choice for larger shipments, although it requires a longer transit time. Customers can select the transportation method that best suits their order size, budget, and delivery timeline.

3. Delivery Time

Upon receiving payment, Tiamulin Fumarate orders are typically processed and shipped within 2–3 business days. This prompt turnaround allows us to meet urgent customer demands, enhancing customer satisfaction and building trust in our reliable and timely service.

Q1: How can I place an order for Tiamulin Fumarate?

A: You can place an order by contacting our customer service team directly. Here’s how to reach us:

•WeChat: +86-18663729963, +86-13589106478

•Skype: sunnylee886

•Email: maggie@hope-biotech.com, sunny@hope-biotech.com

•Mobile: +86-18663729963, +86-13589106478

Our team will assist you promptly with the ordering process and answer any questions you may have.

Q2: What is the minimum order quantity (MOQ) for Tiamulin Fumarate?

A: Our standard MOQ for Tiamulin Fumarate is 0.5 kg. If you require a specific quantity, please reach out to us, and we will do our best to meet your needs.

Q3: What certifications does your company have for Tiamulin Fumarate?

A: Our production facility is certified with GMP and ISO 9001 standards, ensuring rigorous quality control and top-quality manufacturing. We also hold FSC and CEP certifications, demonstrating our commitment to producing Tiamulin Fumarate at the highest industry standards for quality, safety, and reliability.

Q4: What is Tiamulin Fumarate used for?

A: Tiamulin Fumarate is an antibiotic widely used in veterinary medicine, particularly effective against mycoplasmas and certain Gram-positive bacteria. It is commonly used to treat respiratory and gastrointestinal infections in livestock, including swine and poultry, enhancing animal health and productivity in intensive farming settings.

Q5: Is Tiamulin Fumarate safe for use in animals?

A: Yes, Tiamulin Fumarate is safe for use in animals when administered as directed by a qualified veterinarian. It is important to follow the recommended dosage and withdrawal periods to ensure optimal therapeutic benefits and minimize potential side effects.

Q6: How does Tiamulin Fumarate work?

A: Tiamulin Fumarate works by inhibiting bacterial protein synthesis. It binds to the 50S ribosomal subunit, preventing the growth and replication of bacteria. This mechanism makes it particularly effective against respiratory pathogens, such as Mycoplasma spp. and Actinobacillus pleuropneumoniae, in livestock.

Q7: Can Tiamulin Fumarate be used for both poultry and swine?

A: Yes, Tiamulin Fumarate is suitable for use in both poultry and swine. It is especially effective in controlling mycoplasma-related respiratory infections, making it a versatile antibiotic choice for livestock health management.

Q8: How should Tiamulin Fumarate be stored?

A: Store Tiamulin Fumarate in a cool, dry place, away from direct sunlight and moisture. Proper storage conditions help preserve the product’s stability and efficacy over its shelf life.

Q9: What is the shelf life of Tiamulin Fumarate?

A: Tiamulin Fumarate has a shelf life of 2 years when stored under recommended conditions. This ensures the product maintains its quality, potency, and effectiveness over time.

Q10: Can I get a Certificate of Analysis (CoA) for Tiamulin Fumarate?

A: Yes, we provide a Certificate of Analysis (CoA) for each batch of Tiamulin Fumarate. The CoA includes detailed information on purity, potency, and compliance with quality standards. It is available upon request to ensure transparency and guarantee product quality.