1. Name and Synonyms

The product is officially named Neomycin Sulfate and is sometimes referred to in veterinary settings as simply Neomycin. This name is well-recognized in clinical and research environments, making it easy to identify across various applications in animal health.

2. Chemical Identification

Neomycin Sulfate is identified with the CAS number 1405-10-3, serving as a unique identifier in the pharmaceutical and veterinary fields. This CAS number ensures accuracy in research, production, and quality control processes.

3. Appearance and Physical Properties

Neomycin Sulfate typically appears as a white to off-white crystalline powder. This characteristic helps support product identification and quality control throughout the manufacturing and distribution process.

4. Purity and Solubility

Neomycin Sulfate is produced at a high purity level of ≥ 95%, ensuring reliable effectiveness in veterinary applications. It is freely soluble in water, slightly soluble in methanol, and practically insoluble in ethanol and acetone. This solubility profile allows for flexible formulation options in veterinary applications, particularly in feed and water-based treatments for livestock.

5. Molecular Structure

The molecular formula of Neomycin Sulfate is C₂₃H₄₆N₆O₁₃ · xH₂SO₄, with a variable sulfate content. Its structure enables the antibiotic to bind effectively to bacterial ribosomes, interfering with protein synthesis and inhibiting bacterial growth. This mechanism makes Neomycin Sulfate a potent choice for managing bacterial infections in livestock, especially those related to enteric bacteria.

1. Antibiotic Type

Neomycin Sulfate belongs to the aminoglycoside class of antibiotics, which are effective against a wide range of Gram-negative bacteria and some Gram-positive bacteria. Aminoglycosides work by inhibiting bacterial protein synthesis through binding to the 30S ribosomal subunit, which interrupts the process of translating RNA into proteins. This mechanism makes Neomycin Sulfate highly effective for treating infections in livestock, particularly those affecting the digestive and skin systems.

2. Antibacterial Spectrum

2.1 Gram-Negative Bacteria

Neomycin Sulfate is particularly effective against a variety of Gram-negative bacteria, including Escherichia coli, Klebsiella pneumoniae, Salmonella spp., and Shigella spp. These bacteria are common pathogens in livestock, often responsible for intestinal and systemic infections. Neomycin’s potency against these bacteria makes it a valuable option for treating gastrointestinal infections and related conditions in animals, especially swine and poultry.

2.2 Limited Activity on Gram-Positive Bacteria

While Neomycin Sulfate is primarily effective against Gram-negative organisms, it also exhibits some activity against Gram-positive bacteria, such as Staphylococcus aureus. However, its use against Gram-positive infections is limited, and it is generally not the first choice for treating these types of pathogens in animals. Neomycin’s selective efficacy is beneficial in targeted applications within animal husbandry.

2.3 Other Microorganisms

Neomycin Sulfate has limited activity against anaerobic bacteria and is not effective against mycoplasmas or other atypical bacteria. Its use is primarily focused on infections caused by Gram-negative pathogens, which makes it well-suited for enteric and topical applications where such pathogens are prevalent.

3. Comparison of Antibacterial Activity

Neomycin Sulfate is well-known for its potent activity against Gram-negative bacteria, especially in the gastrointestinal tract. Compared to other antibiotics, it has limited absorption when taken orally, which makes it particularly useful for targeting localized infections in the digestive system without impacting the systemic microbiota. This characteristic minimizes resistance development and makes it safer for intensive use in livestock.

4. Application Fields

Neomycin Sulfate is widely used in veterinary medicine, particularly for the treatment of enteric and skin infections in livestock, including swine, poultry, and cattle. Its ability to control bacterial growth in the digestive system helps to reduce morbidity associated with bacterial infections, thereby promoting animal health and improving productivity in animal husbandry. Neomycin Sulfate is often applied as a feed additive or topical solution in intensive farming operations to control infections and support general health in livestock.

1. Shelf Life

Neomycin Sulfate has a shelf life of 2 years when stored under recommended conditions. During this period, the product retains its quality, effectiveness, and stability, ensuring reliable antibacterial activity for veterinary and livestock applications.

2. Testing Indicators and Standards

2.1 Appearance

Neomycin Sulfate should appear as a white to off-white crystalline powder. Any deviation from this appearance could signal potential quality issues, making it a key factor in quality control.

2.2 Identification

The product is identified through multiple analytical methods, including High-Performance Liquid Chromatography (HPLC), which confirms the identity of Neomycin Sulfate by retention time (tR). Additional chemical tests verify the product’s authenticity and purity, ensuring quality across batches.

2.3 pH Value

The pH of a 1% solution of Neomycin Sulfate in water should range between 4.5 and 7.5. This pH range is important for maintaining product stability and bioactivity, as deviations may affect effectiveness in veterinary treatments.

2.4 Specific Absorbance

At 280 nm, the specific absorbance of Neomycin Sulfate should meet the required range. This measurement confirms product purity and ensures consistency with the expected absorbance profile, which is critical for quality assurance.

2.5 Light Absorbing Impurities

At 420 nm, light-absorbing impurities must not exceed specified limits. Controlling these impurities helps to maintain product stability, ensuring Neomycin Sulfate remains effective in veterinary applications.

2.6 Related Substances Content

Strict limits are imposed on related substances to ensure high purity. Impurities, particularly related aminoglycoside compounds, must be kept below 0.5% to uphold product quality and ensure efficacy in treating infections in livestock.

2.7 Heavy Metals Content

The heavy metals content in Neomycin Sulfate should not exceed 20 ppm. Low levels of heavy metals are crucial for product safety, minimizing potential health risks for animals when used in veterinary treatments.

2.8 Water Content

Water content should be controlled within a range of 4.0% to 6.0%. Excess moisture can compromise the stability and quality of Neomycin Sulfate, so maintaining it within this range ensures product consistency and prevents degradation.

2.9 Residue on Ignition (Ash Content)

The residue on ignition, or ash content, should not exceed 0.2%. A low ash content reflects high product purity and the absence of unwanted inorganic contaminants.

2.10 Content Determination

The active content of Neomycin Sulfate should range between 95.0% and 102.0%. Ensuring the active ingredient is within this range guarantees the product’s effectiveness in veterinary applications, providing reliable antibacterial action for treating livestock infections.

1. Packaging

Neomycin Sulfate is packaged in fiber drums, available in two standard sizes: 15 kg/drum and 25 kg/drum. This packaging method effectively protects the product from environmental factors such as moisture, light, and oxidation, ensuring the product’s stability during storage and transportation. The fiber drums are designed for easy handling, facilitating logistics and inventory management in both small and large veterinary supply operations.

2. Transportation Modes

2.1 Express Shipping

For smaller or time-sensitive orders, we offer express shipping via reputable international carriers, including DHL, TNT, FedEx, and other trusted providers. These express options guarantee fast and reliable delivery, meeting urgent customer requirements.

2.2 Air and Sea Freight

For bulk orders, air or sea freight options are available. Air freight provides a quicker delivery option for larger quantities but may involve higher costs. Sea freight, while more economical for large shipments, has a longer transit time. Customers can select the transportation method that best aligns with their order size, budget, and required delivery timeframe.

3. Delivery Time

Once payment is received, Neomycin Sulfate orders are typically processed and shipped within 2–3 business days. This fast turnaround ensures we meet the urgent demands of our customers, building confidence in our reliable and responsive service.

Q1: How can I place an order for Neomycin Sulfate?

A: To place an order for Neomycin Sulfate, please contact our customer service team for immediate support. You may also reach us through the following options:

•WeChat: +86-18663729963, +86-13589106478

•Skype: sunnylee886

•Email: maggie@hope-biotech.com, sunny@hope-biotech.com

•Mobile: +86-18663729963, +86-13589106478

Q2: What is the minimum order quantity (MOQ) for Neomycin Sulfate?

A: Our typical MOQ for Neomycin Sulfate is 0.5 kg. However, we’re flexible to discuss specific quantity needs—just reach out, and we’ll work to meet your requirements.

Q3: What certifications does your company hold for Neomycin Sulfate?

A: Our manufacturing facility is certified with GMP, ISO 9001, FSC, and CEP standards. These certifications reflect our dedication to maintaining the highest levels of quality and safety in our production processes, assuring you of Neomycin Sulfate’s consistent quality and compliance with international standards.

Q4: What is Neomycin Sulfate used for?

A: Neomycin Sulfate is a potent broad-spectrum antibiotic that’s widely used in veterinary medicine. It’s effective against various Gram-negative bacteria and is typically prescribed for treating intestinal infections, as well as skin and wound infections in livestock like cattle, swine, and poultry.

Q5: Is Neomycin Sulfate safe for use in animals?

A: Yes, when used according to veterinary recommendations, Neomycin Sulfate is safe and effective for animal treatments. Following the prescribed dosage ensures optimal outcomes and reduces the risk of side effects.

Q6: How does Neomycin Sulfate work?

A: Neomycin Sulfate works by interfering with bacterial protein synthesis. It binds to the 30S ribosomal subunit, halting protein production, which ultimately inhibits or kills susceptible bacteria. This makes it effective against a variety of Gram-negative bacterial infections.

Q7: Can Neomycin Sulfate be used for both poultry and other livestock?

A: Yes, Neomycin Sulfate is commonly used for different livestock, including poultry, cattle, and swine. Its broad-spectrum effectiveness against bacterial infections makes it a valuable tool for maintaining health across various animal species.

Q8: How should Neomycin Sulfate be stored?

A: Neomycin Sulfate should be stored in a cool, dry place, away from direct light and moisture. Proper storage ensures the product’s stability and effectiveness throughout its shelf life.

Q9: What is the recommended dosage of Neomycin Sulfate for animals?

A: The dosage varies depending on the type of animal and severity of infection. It’s best to consult a licensed veterinarian to determine the most suitable dosage and treatment duration for specific cases.

Q10: Can I receive a Certificate of Analysis (CoA) for Neomycin Sulfate?

A: Absolutely. We provide a Certificate of Analysis (CoA) with each batch of Neomycin Sulfate, detailing information on purity, potency, and compliance with quality standards. This document is available upon request for complete transparency and quality assurance.