1. Name and Synonyms

The product is officially named Marbofloxacin and is sometimes referred to as a fluoroquinolone antibacterial agent in certain veterinary settings. This name is widely recognized in clinical and research environments, ensuring easy identification across various applications in animal health.

2. Chemical Identification

Marbofloxacin is identified with the CAS number 115550-35-1, which serves as a unique identifier in pharmaceutical and veterinary fields. This CAS number ensures accuracy in research, production, and quality control processes.

3. Appearance and Physical Properties

Marbofloxacin typically appears as a white to pale yellow crystalline powder. This physical characteristic supports product identification and aids in quality control throughout the manufacturing and distribution process.

4. Purity and Solubility

Marbofloxacin has a high purity level of ≥ 98%, ensuring effective results in veterinary applications. It is sparingly soluble in water, more soluble in methanol, and slightly soluble in ethanol, providing flexibility in formulation options for veterinary treatments in livestock and poultry.

5. Molecular Structure

The molecular formula of Marbofloxacin is C₁₇H₁₉FN₄O₄ with a molecular weight of approximately 363.4 g/mol. This structure enables its mechanism of action, which involves inhibiting bacterial DNA gyrase and topoisomerase IV. This inhibition disrupts bacterial DNA replication, making Marbofloxacin an effective choice for controlling a wide range of bacterial infections in livestock.

1. Antibiotic Type

Marbofloxacin belongs to the fluoroquinolone class of antibiotics. Fluoroquinolones are broad-spectrum antibiotics effective against a wide range of Gram-negative bacteria and some Gram-positive bacteria. Marbofloxacin works by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication and repair. This mechanism disrupts bacterial cell division, making Marbofloxacin effective for treating various infections in livestock, particularly respiratory, urinary, and systemic infections.

2. Antibacterial Spectrum

2.1 Gram-Negative Bacteria

Marbofloxacin is highly effective against a range of Gram-negative bacteria, including Escherichia coli, Pasteurella multocida, Klebsiella pneumoniae, and Salmonella spp. These pathogens are commonly responsible for respiratory, urinary, and systemic infections in animals, particularly in cattle, swine, and poultry. Marbofloxacin’s potency against these Gram-negative bacteria makes it a valuable choice for managing bacterial diseases in intensive livestock farming.

2.2 Gram-Positive Bacteria

Marbofloxacin also exhibits activity against certain Gram-positive bacteria, such as Staphylococcus aureus and some Streptococcus species. Staphylococcus aureus can lead to skin, wound, and soft tissue infections, while Streptococcus species are associated with respiratory and systemic infections. Marbofloxacin’s broad activity against both Gram-negative and some Gram-positive pathogens allows it to address mixed bacterial infections in livestock effectively.

2.3 Other Microorganisms

In addition to its antibacterial activity, Marbofloxacin is active against certain mycoplasmas, such as Mycoplasma bovis and Mycoplasma hyopneumoniae, which are common respiratory pathogens in cattle and swine. This activity against mycoplasmas expands Marbofloxacin’s application in treating respiratory diseases in livestock, especially in cases involving both Gram-negative bacteria and mycoplasmas.

3. Comparison of Antibacterial Activity

Marbofloxacin is notable for its strong tissue penetration and rapid bactericidal activity, making it effective in controlling respiratory, urinary, and systemic infections. Compared to older antibiotics, Marbofloxacin provides fast and potent inhibition of bacterial growth, making it an ideal choice when quick and comprehensive treatment is necessary. Its efficacy against both Gram-negative bacteria and mycoplasmas also offers a significant advantage over antibiotics with narrower spectrums.

4. Application Fields

Marbofloxacin is widely used in veterinary medicine, particularly for treating respiratory, urinary, and systemic infections in livestock, including cattle, swine, and poultry. It is highly effective in managing bacterial infections that can threaten animal health and productivity, making it essential in disease prevention and control for intensive farming environments. Due to its broad-spectrum antibacterial properties, Marbofloxacin is an ideal choice for preventing and treating infections in livestock, supporting animal welfare and maintaining productivity in animal husbandry operations.

1. Shelf Life

Marbofloxacin has a shelf life of 2 years when stored under recommended conditions. Within this period, the product maintains its quality, effectiveness, and stability, ensuring it delivers the intended antibacterial effects for veterinary applications.

2. Testing Indicators and Standards

2.1 Appearance

Marbofloxacin should appear as a white to pale yellow crystalline powder. Any deviation from this appearance may indicate potential quality issues, serving as a fundamental quality control measure.

2.2 Identification

The product is identified through various analytical methods, including High-Performance Liquid Chromatography (HPLC), where the retention time (tR) is used to confirm the identity of Marbofloxacin. Additional chemical tests verify purity and authenticity, ensuring quality from multiple perspectives.

2.3 pH Value

The pH of a 1% Marbofloxacin solution in water should range between 4.0 and 5.5. Maintaining this pH range is crucial for stability and biological activity, as deviations can affect the product’s effectiveness.

2.4 Specific Absorbance

At 293 nm, the specific absorbance of Marbofloxacin should meet the required range to confirm quality. This measurement verifies purity and alignment with the expected absorbance profile.

2.5 Light Absorbing Impurities

At 420 nm, light-absorbing impurities should not exceed specified limits. Controlling these impurities helps maintain product stability and ensures Marbofloxacin’s efficacy in veterinary applications.

2.6 Related Substances Content

Strict limits are set for related substances to ensure high purity. Structurally related fluoroquinolone impurities must be kept below 0.5% to maintain product quality and effectiveness in treating infections.

2.7 Heavy Metals Content

The heavy metals content in Marbofloxacin should not exceed 10 ppm. Low levels of heavy metals are essential for product safety, minimizing any adverse effects on animal health.

2.8 Water Content

Water content should be controlled between 0.5% and 1.5%. Excess moisture can affect the stability and quality of Marbofloxacin, so maintaining it within this range ensures consistency and prevents degradation.

2.9 Residue on Ignition (Ash Content)

The residue on ignition, or ash content, should not exceed 0.1%. This low ash content indicates high purity, free from unwanted inorganic contaminants.

2.10 Content Determination

The potency of Marbofloxacin is determined based on its active content, which should range between 98.0% and 102.0%. Ensuring the active content meets this specification guarantees the product’s effectiveness in veterinary applications, delivering reliable antibacterial activity.

1. GMP Compliance

Our facility operates in full compliance with Good Manufacturing Practice (GMP) standards, ensuring high-quality production processes and consistent product quality for Marbofloxacin. This certification guarantees that each batch meets stringent industry standards for safety and efficacy.

2. ISO Certification

Shandong Hope Biotech holds an ISO 9001 certification, demonstrating our commitment to quality management and continuous improvement. This certification reflects our dedication to maintaining high standards in the production of veterinary pharmaceuticals, including Marbofloxacin.

3. Veterinary Drug Certification

Marbofloxacin is produced under regulatory approval for veterinary use, meeting all necessary certifications and standards required for antibiotics used in animal health. This certification ensures that our Marbofloxacin products are safe, effective, and meet all industry-specific regulatory standards.

4. Third-Party Testing

Each batch of Marbofloxacin undergoes independent third-party testing to verify its purity, potency, and safety. Certificates of Analysis (CoA) are available upon request, providing transparency and reinforcing our commitment to delivering quality-assured products to our customers.

5. Environmental and Safety Standards

Our production practices for Marbofloxacin adhere to strict environmental and safety regulations. We prioritize responsible manufacturing processes that minimize environmental impact, uphold worker safety, and align with industry-leading sustainability standards.

Q1: How can I place an order for Marbofloxacin?

A: You can place an order by contacting our online customer service team for immediate assistance. Alternatively, you can reach us via the following methods:

• WeChat: +86-18663729963, +86-13589106478

• Skype: sunnylee886

• Email: maggie@hope-biotech.com, sunny@hope-biotech.com

• Mobile: +86-18663729963, +86-13589106478

Q2: What is the minimum order quantity (MOQ) for Marbofloxacin?

A: Our MOQ is 0.5 kg. However, if you have specific quantity requirements, please discuss them with us, and we will do our best to accommodate your needs.

Q3: What certifications does your company have for Marbofloxacin?

A: Our production facility is certified with GMP, ISO 9001, FSC, and CEP, ensuring that our manufacturing practices meet high-quality standards for safety, reliability, and efficacy.

Q4: What is Marbofloxacin used for?

A: Marbofloxacin is a broad-spectrum fluoroquinolone antibiotic commonly used in veterinary medicine. It is effective against respiratory, urinary, and systemic infections in livestock, including cattle, swine, and poultry, due to its potency against various Gram-negative bacteria and some Gram-positive bacteria.

Q5: Is Marbofloxacin safe for use in animals?

A: Yes, when used according to veterinary guidance, Marbofloxacin is safe and effective for treating bacterial infections in animals. Proper dosage and administration are essential for optimal therapeutic outcomes and minimizing side effects.

Q6: How does Marbofloxacin work?

A: Marbofloxacin inhibits bacterial DNA replication by targeting bacterial DNA gyrase and topoisomerase IV enzymes. This mechanism halts bacterial growth, making Marbofloxacin effective against a wide range of bacterial pathogens, particularly in treating respiratory and urinary infections in animals.

Q7: Can Marbofloxacin be used for both poultry and livestock?

A: Yes, Marbofloxacin is suitable for various types of livestock, including cattle, swine, and poultry. Its broad-spectrum activity makes it a versatile choice for addressing infections across different animal species.

Q8: How should Marbofloxacin be stored?

A: Store Marbofloxacin in a cool, dry place away from light and moisture to maintain its stability and effectiveness. Adhering to proper storage conditions ensures that the product retains its quality throughout its shelf life.

Q9: What is the recommended dosage of Marbofloxacin for animals?

A: The dosage of Marbofloxacin depends on the type of animal, infection severity, and veterinary guidance. We recommend consulting a licensed veterinarian to determine the appropriate dosage for each case.

Q10: Can I get a Certificate of Analysis (CoA) for Marbofloxacin?

A: Yes, we provide a Certificate of Analysis (CoA) for each batch of Marbofloxacin. The CoA includes detailed information on purity, potency, and compliance with quality standards, available upon request for full transparency and quality assurance.